Diabetes is a disease that results from the body’s inability to produce or use insulin. Metabolic syndrome is a group of risk factors that include central (waist) obesity, elevated triglycerides and fasting blood glucose, elevated blood pressure, and low HDL cholesterol. Several of these factors occurring together may increase the risk for conditions such as type 2 diabetes, heart disease or stroke.

  • Two studies specifically evaluated the role of citrus juice with regard to diabetes risk or markers of this disease and found no association. A study of almost 44,000 African American women reported no association between orange/grapefruit juice intake and diabetes incidence.1 A small clinical trial that included 30 subjects who drank three 8-ounce servings of orange juice daily for 60 days reported significant declines in markers of insulin resistance,2 suggesting that the inclusion of orange juice in the diet may be beneficial with respect to insulin resistance, which could lower the overall risk for diabetes.
  • A study of a large cohort of women (Nurses’ Health Study) reported no association between fruit juice consumption and risk for diabetes.3 There are further studies that support no association between orange juice or 100 percent fruit juice intake and risk of diabetes or surrogate markers relating to oxidative stress or inflammation, glucose metabolism, insulin resistance, or diabetes.4-6 
  • A study using NHANES 1999-2004 data reported no association between the consumption of 100 percent fruit juice and risk for obesity or metabolic syndrome, both of which are primary risk factors for diabetes.7


  1. Palmer JR et al. Arch Intern Med. 2008;168:1487-1492.
  2. Cesar T et al. Abstract. Subtropical Technology Conference Proceedings. 58:34. October 18, 2007.
  3. Schulze MB et al. JAMA. 2004;292:927-934.
  4. O'Neil CE et al. Nutrition Research. 2011; 31:673-682.
  5. Fulgoni V et al. Experimental Biology 2011, Abstract #A302 783.3; http://submissions.miracd.com/Verify/EB2011/submission/temp/radF8E8B.pdf. Accessed March 29, 2011.
  6. Morand C et al. AM J Clin Nutr. 2011; 93:73-80.
  7. Pereira MA et al. J Am Coll Nutr. 2010;29:625-629.